Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund–Thomson syndrome

Rothmund–Thomson fibroblasts had replicative lifespans and growth rates within the range for normal fibroblasts; however, they show elevated levels of the stress-associated p38 MAP kinase, suggestive of stress during growth. Treatment with the p38 MAP kinase inhibitor SB203580 increased both lifespa...

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Detalles Bibliográficos
Autores principales: Davis, Terence, Tivey, Hannah S. E., Brook, Amy J. C., Grimstead, Julia W., Rokicki, Michal J., Kipling, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776094/
https://www.ncbi.nlm.nih.gov/pubmed/23001818
http://dx.doi.org/10.1007/s11357-012-9476-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776094/
https://www.ncbi.nlm.nih.gov/pubmed/23001818
http://dx.doi.org/10.1007/s11357-012-9476-9

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