Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()

Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationally restrained amide derivatives as inhibitors PfdUTPase, including both acyclic and cyclic examples....

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Detalles Bibliográficos
Autores principales: Hampton, Shahienaz E., Schipani, Alessandro, Bosch-Navarrete, Cristina, Recio, Eliseo, Kaiser, Marcel, Kahnberg, Pia, González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776224/
https://www.ncbi.nlm.nih.gov/pubmed/23916149
http://dx.doi.org/10.1016/j.bmc.2013.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776224/
https://www.ncbi.nlm.nih.gov/pubmed/23916149
http://dx.doi.org/10.1016/j.bmc.2013.07.004

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