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A Comprehensive Model for the Recognition of Human Telomeres by TRF1

Eukaryotic chromosomes are capped by telomeres, nucleoprotein complexes that prevent chromosome end-to-end fusions and control cell ageing. Two proteins in this complex, telomere repeat binding factors (TRF1 and TRF2), specifically recognise the double-stranded TTAGGG tandem repeat sequence. TRF1 is...

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Detalles Bibliográficos
Autores principales: Garton, Michael, Laughton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776228/
https://www.ncbi.nlm.nih.gov/pubmed/23702294
http://dx.doi.org/10.1016/j.jmb.2013.05.005