How do amino acid substitutions affect the amyloidogenic properties and seeding efficiency of prion peptides

The amino acid sequences in the amyloidogenic region (amino acids 108–144) of several mammalian prion proteins were compared and variations were found to occur at residues 109 (M or L), 112 (M or V), 129 (M, V, or L), 135 (N or S), 138 (M, L, or I), 139 (M or I), and 143 (N or S). Using the bovine P...

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Detalles Bibliográficos
Autores principales: Chuang, Chi-Chen, Liao, Tai-Yan, Chen, Eric H.-L, Chen, Rita P.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776267/
https://www.ncbi.nlm.nih.gov/pubmed/23736988
http://dx.doi.org/10.1007/s00726-013-1522-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776267/
https://www.ncbi.nlm.nih.gov/pubmed/23736988
http://dx.doi.org/10.1007/s00726-013-1522-0

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