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Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

Reorganization of the actin cytoskeleton is responsible for dynamic regulation of endothelial cell (EC) barrier function. Circumferential actin bundles (CAB) promote formation of linear adherens junctions (AJs) and tightening of EC junctions, whereas formation of radial stress fibers (RSF) connected...

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Detalles Bibliográficos
Autores principales: Ando, Koji, Fukuhara, Shigetomo, Moriya, Takahiro, Obara, Yutaro, Nakahata, Norimichi, Mochizuki, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776352/
https://www.ncbi.nlm.nih.gov/pubmed/24019534
http://dx.doi.org/10.1083/jcb.201301115