pH sensing by FAK-His58 regulates focal adhesion remodeling

Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial step in FAK activation is...

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Detalles Bibliográficos
Autores principales: Choi, Chang-Hoon, Webb, Bradley A., Chimenti, Michael S., Jacobson, Matthew P., Barber, Diane L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776353/
https://www.ncbi.nlm.nih.gov/pubmed/24043700
http://dx.doi.org/10.1083/jcb.201302131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776353/
https://www.ncbi.nlm.nih.gov/pubmed/24043700
http://dx.doi.org/10.1083/jcb.201302131

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