Modulation of CD8(+) T cell responses to AAV vectors with IgG-derived MHC class II epitopes

Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed as a solution to the problem; however, the approach suffers from several potenti...

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Detalles Bibliográficos
Autores principales: Hui, Daniel J, Basner-Tschakarjan, Etiena, Chen, Yifeng, Davidson, Robert J, Buchlis, George, Yazicioglu, Mustafa, Pien, Gary C, Finn, Jonathan D, Haurigot, Virginia, Tai, Alex, Scott, David W, Cousens, Leslie P, Zhou, Shangzhen, De Groot, Anne S, Mingozzi, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776637/
https://www.ncbi.nlm.nih.gov/pubmed/23857231
http://dx.doi.org/10.1038/mt.2013.166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776637/
https://www.ncbi.nlm.nih.gov/pubmed/23857231
http://dx.doi.org/10.1038/mt.2013.166

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