Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

Aggregation of α-synuclein (αSyn), the primary protein component in Lewy body inclusions of patients with Parkinson’s disease, arises when the normally soluble intrinsically disordered protein converts to amyloid fibrils. In this work, we provide a mechanistic view of the role of N-terminal acetylat...

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Detalles Bibliográficos
Autores principales: Kang, Lijuan, Janowska, Maria K., Moriarty, Gina M., Baum, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776725/
https://www.ncbi.nlm.nih.gov/pubmed/24058647
http://dx.doi.org/10.1371/journal.pone.0075018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776725/
https://www.ncbi.nlm.nih.gov/pubmed/24058647
http://dx.doi.org/10.1371/journal.pone.0075018

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