Cargando…

Simultaneous Activation of Kras and Inactivation of p53 Induces Soft Tissue Sarcoma and Bladder Urothelial Hyperplasia

The development of the Cre recombinase-controlled (Cre/LoxP) technique allows the manipulation of specific tumorigenic genes, temporarily and spatially. Our original intention of this study was to investigate the role of Kras and p53 in the development of urinary bladder cancer. First, to validate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xiaoping, La Rosa, Francisco G., Genova, Elizabeth Erin, Huber, Kendra, Schaack, Jerome, DeGregori, James, Serkova, Natalie J., Li, Yuan, Su, Lih-Jen, Kessler, Elizabeth, Flaig, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776760/ https://www.ncbi.nlm.nih.gov/pubmed/24058630 http://dx.doi.org/10.1371/journal.pone.0074809

Ejemplares similares

Prostate sarcomas: A radiological mimic for benign prostatic hyperplasia
por: Whish-Wilson, Thomas, et al.
Publicado: (2020)

Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist.
por: Ragozzino, M M, et al.
Publicado: (1991)

Trabectedin in Soft Tissue Sarcomas
por: Petek, Bradley J., et al.
Publicado: (2015)

The induction of urothelial hyperplasia by methyl methanesulphonate and ethyl methanesulphonate.
por: Tudor, R. J., et al.
Publicado: (1983)

Pazopanib in the management of advanced soft tissue sarcomas
por: Cranmer, Lee D, et al.
Publicado: (2016)

Geriatric considerations in the treatment of advanced prostate cancer
por: Kessler, Elizabeth R., et al.
Publicado: (2014)

Epidemiology and Survival of Dogs Diagnosed with Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Stromal Sarcoma and Histiocytic Sarcoma
por: Spröhnle-Barrera, Cleide H., et al.
Publicado: (2022)

Oncological safety of simultaneous transurethral resection of high-grade urothelial carcinoma of the bladder and benign prostatic hyperplasia
por: Sionov, Ben Valery, et al.
Publicado: (2022)

Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis
por: Fujita, Harumi, et al.
Publicado: (2012)

A new role for E2F1 in DNA repair: All for the greater good
por: DeGregori, James
Publicado: (2011)

The special issue on cancer and evolution: Lessons learned
por: DeGregori, James
Publicado: (2020)

Focal nodular hyperplasia that mimicked a liver metastasis from a soft tissue sarcoma: a case report
por: Amisaki, Masataka, et al.
Publicado: (2017)

Statin-related muscle complications masquerading as soft tissue sarcomas
por: Christophel, Elizabeth, et al.
Publicado: (2023)

Soft-tissue Sarcomas
por: Vodanovich, Domagoj Ante, et al.
Publicado: (2018)

miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2
por: Yang, Xiaoping, et al.
Publicado: (2012)

E-cadherin involved in inactivation of WNT/β-catenin signalling in urothelial carcinoma and normal urothelial cells
por: Thievessen, I, et al.
Publicado: (2003)

Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas
por: Takada, Marilia, et al.
Publicado: (2019)

Building a better model of cancer
por: Marusyk, Andriy, et al.
Publicado: (2006)

Somatic maintenance impacts the evolution of mutation rate
por: Rozhok, Andrii, et al.
Publicado: (2019)

A generalized theory of age-dependent carcinogenesis
por: Rozhok, Andrii, et al.
Publicado: (2019)

The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease
por: Marongiu, Fabio, et al.
Publicado: (2022)

Spotlight on olaratumab in the treatment of soft-tissue sarcoma: design, development, and place in therapy
por: Davis, Elizabeth J, et al.
Publicado: (2017)

Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice
por: Tang, Moon-shong, et al.
Publicado: (2019)

Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia
por: Choi, Eunyoung, et al.
Publicado: (2018)

Retroperitoneal soft tissue sarcoma
por: Zepeda, Ernesto, et al.
Publicado: (2007)

Soft Tissue Sarcomas of the Kidney
por: Köhle, Olivia, et al.
Publicado: (2015)

Case of Soft Sarcoma of the Cerebellum
por: Steven, James
Publicado: (1870)

Bone and Soft Tissue Sarcoma
por: Ruggiero, Antonio
Publicado: (2020)

Trabectedin for soft tissue sarcoma
Publicado: (2021)

Local Control Rates of Metastatic Renal Cell Carcinoma (RCC) to Thoracic, Abdominal, and Soft Tissue Lesions Using Stereotactic Body Radiotherapy (SBRT)
por: Altoos, Basel, et al.
Publicado: (2015)

Oncogenic drivers and mitochondrial dependency
por: Alvarez-Calderon, Francesca, et al.
Publicado: (2015)

Decoy fitness peaks, tumor suppression, and aging
por: Higa, Kelly C., et al.
Publicado: (2019)

Approaching Cancer Evolution from Different Angles
por: Ciccarelli, Francesca D., et al.
Publicado: (2020)

The three dimensions of somatic evolution: Integrating the role of genetic damage, life‐history traits, and aging in carcinogenesis
por: Rozhok, Andrii I., et al.
Publicado: (2020)

Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome–associated leukemia
por: Evans, Edward J., et al.
Publicado: (2022)

CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients
por: Greither, Thomas, et al.
Publicado: (2017)

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis
por: Henry, Curtis J., et al.
Publicado: (2017)

Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation
por: Lefort, Sylvain, et al.
Publicado: (2019)

New therapeutics for soft tissue sarcomas: Overview of current immunotherapy and future directions of soft tissue sarcomas
por: Seong, Gyuhee, et al.
Publicado: (2023)

A Peek into Tropomyosin Binding and Unfolding on the Actin Filament
por: Singh, Abhishek, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ug06h507dgjmlvmde3scp8ldsv