Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ(42) induced cytotoxicity

Alzheimer's disease (AD) is characterized by neurofibrillary tangles, senile plaques and neuronal loss. Amyloid beta (Aβ) is proposed to elicit neuronal loss through cell surface receptors. As Aβ shares common binding partners with the 37 kDa/67 kDa laminin receptor (LRP/LR), we investigated wh...

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Detalles Bibliográficos
Autores principales: Da Costa Dias, Bianca, Jovanovic, Katarina, Gonsalves, Danielle, Moodley, Kiashanee, Reusch, Uwe, Knackmuss, Stefan, Penny, Clement, Weinberg, Marc S., Little, Melvyn, Weiss, Stefan F. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776967/
https://www.ncbi.nlm.nih.gov/pubmed/24048171
http://dx.doi.org/10.1038/srep02702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776967/
https://www.ncbi.nlm.nih.gov/pubmed/24048171
http://dx.doi.org/10.1038/srep02702

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