Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo

BACKGROUND: Antibody drug conjugates (ADCs) and immunotoxins (ITs) are promising anticancer immunotherapeutics. Despite their encouraging performance in clinical trials, both ADCs and ITs often suffer from disadvantages such as stoichiometrically undefined chemical linkage of the cytotoxic payload (...

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Detalles Bibliográficos
Autores principales: Hristodorov, D, Mladenov, R, Pardo, A, Pham, A-T, Huhn, M, Fischer, R, Thepen, T, Barth, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776980/
https://www.ncbi.nlm.nih.gov/pubmed/23942071
http://dx.doi.org/10.1038/bjc.2013.457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776980/
https://www.ncbi.nlm.nih.gov/pubmed/23942071
http://dx.doi.org/10.1038/bjc.2013.457

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