Assessing association between protein truncating variants and quantitative traits

Motivation: In sequencing studies of common diseases and quantitative traits, power to test rare and low frequency variants individually is weak. To improve power, a common approach is to combine statistical evidence from several genetic variants in a region. Major challenges are how to do the combi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rivas, Manuel A., Pirinen, Matti, Neville, Matthew J., Gaulton, Kyle J., Moutsianas, Loukas, Lindgren, Cecilia M., Karpe, Fredrik, McCarthy, Mark I., Donnelly, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777107/
https://www.ncbi.nlm.nih.gov/pubmed/23860716
http://dx.doi.org/10.1093/bioinformatics/btt409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777107/
https://www.ncbi.nlm.nih.gov/pubmed/23860716
http://dx.doi.org/10.1093/bioinformatics/btt409

Ejemplares similares