Design and Exploratory Neuropharmacological Evaluation of Novel Thyrotropin-Releasing Hormone Analogs and Their Brain-Targeting Bioprecursor Prodrugs

Efforts to take advantage of the beneficial activities of thyrotropin-releasing hormone (TRH) in the brain are hampered by its poor metabolic stability and lack of adequate central nervous system bioavailability. We report here novel and metabolically stable analogs that we derived from TRH by repla...

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Detalles Bibliográficos
Autores principales: Prokai-Tatrai, Katalin, Nguyen, Vien, Szarka, Szabolcs, Konya, Krisztina, Prokai, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777413/
https://www.ncbi.nlm.nih.gov/pubmed/24058724
http://dx.doi.org/10.3390/pharmaceutics5020318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777413/
https://www.ncbi.nlm.nih.gov/pubmed/24058724
http://dx.doi.org/10.3390/pharmaceutics5020318

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