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Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis
Pyruvate kinase catalyzes the rate-limiting final step of glycolysis, generating adenosine triphosphate (ATP) and pyruvate. The M2 tumor-specific isoform of pyruvate kinase (PKM2) promotes glucose uptake and lactate production in the presence of oxygen, known as aerobic glycolysis or the Warburg eff...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Sun Yat-sen University Cancer Center
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777463/ https://www.ncbi.nlm.nih.gov/pubmed/22200182 http://dx.doi.org/10.5732/cjc.011.10446 |