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Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
S-phase kinase-associated protein 2 (Skp2) belongs to the F-box protein family. It is a component of the SCF E3 ubiquitin ligase complex. Skp2 has been shown to regulate cellular proliferation by targeting several cell cycle-regulated proteins for ubiquitination and degradation, including cyclin-dep...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Sun Yat-sen University Cancer Center
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777478/ https://www.ncbi.nlm.nih.gov/pubmed/22200179 http://dx.doi.org/10.5732/cjc.011.10319 |