Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks

Sapacitabine is an orally bioavailable prodrug of the nucleoside analog 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosylcytosine (CNDAC). Both the prodrug and active metabolite are in clinical trials for hematologic malignancies and/or solid tumors. CNDAC has a unique mechanism of action: after inco...

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Detalles Bibliográficos
Autores principales: Liu, Xiao-Jun, Nowak, Billie, Wang, Ya-Qing, Plunkett, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777512/
https://www.ncbi.nlm.nih.gov/pubmed/22739266
http://dx.doi.org/10.5732/cjc.012.10077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777512/
https://www.ncbi.nlm.nih.gov/pubmed/22739266
http://dx.doi.org/10.5732/cjc.012.10077

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