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Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis

PURPOSE: To systematically investigate the effects of dietary flavonoids and flavonoid subclasses on the risk of smoking-related cancer in observational studies. METHODS: Summary estimates and corresponding standard errors were calculated using the multivariate-adjusted odds ratio (OR) or relative r...

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Autores principales: Woo, Hae Dong, Kim, Jeongseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777962/
https://www.ncbi.nlm.nih.gov/pubmed/24069431
http://dx.doi.org/10.1371/journal.pone.0075604
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author Woo, Hae Dong
Kim, Jeongseon
author_facet Woo, Hae Dong
Kim, Jeongseon
author_sort Woo, Hae Dong
collection PubMed
description PURPOSE: To systematically investigate the effects of dietary flavonoids and flavonoid subclasses on the risk of smoking-related cancer in observational studies. METHODS: Summary estimates and corresponding standard errors were calculated using the multivariate-adjusted odds ratio (OR) or relative risk (RR) and 95% CI of selected studies and weighted by the inverse variance. RESULTS: A total of 35 studies, including 19 case-controls (9,525 cases and 15,835 controls) and 15 cohort studies (988,082 subjects and 8,161 cases), were retrieved for the meta-analysis. Total dietary flavonoids and most of the flavonoid subclasses were inversely associated with smoking-related cancer risk (OR: 0.82, 95% CI: 0.72-0.93). In subgroup analyses by cancer site, significant associations were observed in aerodigestive tract and lung cancers. Total dietary flavonoid intake was significantly associated with aerodigestive tract cancer risk (OR: 0.67, 95% CI: 0.54-0.83) marginally associated with lung cancer risk (OR: 0.84, 95% CI: 0.71-1.00). Subgroup analyses by smoking status showed significantly different results. The intake of total flavonoids, flavonols, flavones, and flavanones, as well as the flavonols quercetin and kaempferol was significantly associated with decreased risk of smoking-related cancer in smokers, whereas no association was observed in non-smokers, except for flavanones. In meta-analysis for the effect of subclasses of dietary flavonoids by cancer type, aerodigestive tract cancer was inversely associated with most flavonoid subclasses. CONCLUSION: The protective effects of flavonoids on smoking-related cancer risk varied across studies, but the overall results indicated that intake of dietary flavonoids, especially flavonols, was inversely associated with smoking-related cancer risk. The protective effects of flavonoids on smoking-related cancer risk were more prominent in smokers.
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spelling pubmed-37779622013-09-25 Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis Woo, Hae Dong Kim, Jeongseon PLoS One Research Article PURPOSE: To systematically investigate the effects of dietary flavonoids and flavonoid subclasses on the risk of smoking-related cancer in observational studies. METHODS: Summary estimates and corresponding standard errors were calculated using the multivariate-adjusted odds ratio (OR) or relative risk (RR) and 95% CI of selected studies and weighted by the inverse variance. RESULTS: A total of 35 studies, including 19 case-controls (9,525 cases and 15,835 controls) and 15 cohort studies (988,082 subjects and 8,161 cases), were retrieved for the meta-analysis. Total dietary flavonoids and most of the flavonoid subclasses were inversely associated with smoking-related cancer risk (OR: 0.82, 95% CI: 0.72-0.93). In subgroup analyses by cancer site, significant associations were observed in aerodigestive tract and lung cancers. Total dietary flavonoid intake was significantly associated with aerodigestive tract cancer risk (OR: 0.67, 95% CI: 0.54-0.83) marginally associated with lung cancer risk (OR: 0.84, 95% CI: 0.71-1.00). Subgroup analyses by smoking status showed significantly different results. The intake of total flavonoids, flavonols, flavones, and flavanones, as well as the flavonols quercetin and kaempferol was significantly associated with decreased risk of smoking-related cancer in smokers, whereas no association was observed in non-smokers, except for flavanones. In meta-analysis for the effect of subclasses of dietary flavonoids by cancer type, aerodigestive tract cancer was inversely associated with most flavonoid subclasses. CONCLUSION: The protective effects of flavonoids on smoking-related cancer risk varied across studies, but the overall results indicated that intake of dietary flavonoids, especially flavonols, was inversely associated with smoking-related cancer risk. The protective effects of flavonoids on smoking-related cancer risk were more prominent in smokers. Public Library of Science 2013-09-19 /pmc/articles/PMC3777962/ /pubmed/24069431 http://dx.doi.org/10.1371/journal.pone.0075604 Text en © 2013 Woo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Woo, Hae Dong
Kim, Jeongseon
Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis
title Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis
title_full Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis
title_fullStr Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis
title_full_unstemmed Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis
title_short Dietary Flavonoid Intake and Smoking-Related Cancer Risk: A Meta-Analysis
title_sort dietary flavonoid intake and smoking-related cancer risk: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777962/
https://www.ncbi.nlm.nih.gov/pubmed/24069431
http://dx.doi.org/10.1371/journal.pone.0075604
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