Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

The tight control of gene expression at the level of both transcription and post-transcriptional RNA processing is essential for mammalian development. We here investigate the role of protein arginine methyltransferase 5 (PRMT5), a putative splicing regulator and transcriptional cofactor, in mammali...

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Detalles Bibliográficos
Autores principales: Bezzi, Marco, Teo, Shun Xie, Muller, Julius, Mok, Wei Chuen, Sahu, Sanjeeb Kumar, Vardy, Leah A., Bonday, Zahid Q., Guccione, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778243/
https://www.ncbi.nlm.nih.gov/pubmed/24013503
http://dx.doi.org/10.1101/gad.219899.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778243/
https://www.ncbi.nlm.nih.gov/pubmed/24013503
http://dx.doi.org/10.1101/gad.219899.113

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