Cargando…
An experimental test on the probability of extinction of new genetic variants
In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane’s insight that new benefici...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778522/ https://www.ncbi.nlm.nih.gov/pubmed/24030070 http://dx.doi.org/10.1038/ncomms3417 |
_version_ | 1782285117942661120 |
---|---|
author | Chelo, Ivo M. Nédli, Judit Gordo, Isabel Teotónio, Henrique |
author_facet | Chelo, Ivo M. Nédli, Judit Gordo, Isabel Teotónio, Henrique |
author_sort | Chelo, Ivo M. |
collection | PubMed |
description | In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane’s insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing initial numbers of beneficial alleles, as expected, by performing invasion experiments with inbred lines of the nematode Caenorhabditis elegans. We further show that the extinction rates of deleterious alleles are higher than those of beneficial alleles, also as expected. Interestingly, we also find that for these inbred lines, when at intermediate frequencies, the fate of invaders might not result in their ultimate fixation or loss but on their maintenance. Our study confirms the key results from classical population genetics and highlights that the nature of adaptation can be complex. |
format | Online Article Text |
id | pubmed-3778522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37785222013-09-23 An experimental test on the probability of extinction of new genetic variants Chelo, Ivo M. Nédli, Judit Gordo, Isabel Teotónio, Henrique Nat Commun Article In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane’s insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing initial numbers of beneficial alleles, as expected, by performing invasion experiments with inbred lines of the nematode Caenorhabditis elegans. We further show that the extinction rates of deleterious alleles are higher than those of beneficial alleles, also as expected. Interestingly, we also find that for these inbred lines, when at intermediate frequencies, the fate of invaders might not result in their ultimate fixation or loss but on their maintenance. Our study confirms the key results from classical population genetics and highlights that the nature of adaptation can be complex. Nature Pub. Group 2013-09-13 /pmc/articles/PMC3778522/ /pubmed/24030070 http://dx.doi.org/10.1038/ncomms3417 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Chelo, Ivo M. Nédli, Judit Gordo, Isabel Teotónio, Henrique An experimental test on the probability of extinction of new genetic variants |
title | An experimental test on the probability of extinction of new genetic variants |
title_full | An experimental test on the probability of extinction of new genetic variants |
title_fullStr | An experimental test on the probability of extinction of new genetic variants |
title_full_unstemmed | An experimental test on the probability of extinction of new genetic variants |
title_short | An experimental test on the probability of extinction of new genetic variants |
title_sort | experimental test on the probability of extinction of new genetic variants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778522/ https://www.ncbi.nlm.nih.gov/pubmed/24030070 http://dx.doi.org/10.1038/ncomms3417 |
work_keys_str_mv | AT cheloivom anexperimentaltestontheprobabilityofextinctionofnewgeneticvariants AT nedlijudit anexperimentaltestontheprobabilityofextinctionofnewgeneticvariants AT gordoisabel anexperimentaltestontheprobabilityofextinctionofnewgeneticvariants AT teotoniohenrique anexperimentaltestontheprobabilityofextinctionofnewgeneticvariants AT cheloivom experimentaltestontheprobabilityofextinctionofnewgeneticvariants AT nedlijudit experimentaltestontheprobabilityofextinctionofnewgeneticvariants AT gordoisabel experimentaltestontheprobabilityofextinctionofnewgeneticvariants AT teotoniohenrique experimentaltestontheprobabilityofextinctionofnewgeneticvariants |