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RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue

Helicases that both unwind and rewind DNA have central roles in DNA repair and genetic recombination. In contrast to unwinding, DNA rewinding by helicases has proved difficult to characterize biochemically because of its thermodynamically downhill nature. Here we use single-molecule assays to mechan...

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Detalles Bibliográficos
Autores principales: Manosas, Maria, Perumal, Senthil K., Bianco, Piero, Ritort, Felix, Benkovic, Stephen J., Croquette, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778716/
https://www.ncbi.nlm.nih.gov/pubmed/24013402
http://dx.doi.org/10.1038/ncomms3368