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Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy

Severe malaria during pregnancy is associated with accumulation of parasite-infected erythrocytes in the placenta due to interactions between VAR2CSA protein, expressed on the surface of infected-erythrocytes, and placental chondroitin sulfate proteoglycans (CSPG). VAR2CSA contains multiple CSPG-bin...

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Detalles Bibliográficos
Autores principales: Khunrae, Pongsak, Philip, Judith M.D., Bull, Duncan R., Higgins, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778748/
https://www.ncbi.nlm.nih.gov/pubmed/19695262
http://dx.doi.org/10.1016/j.jmb.2009.08.027