Cargando…

Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy

Severe malaria during pregnancy is associated with accumulation of parasite-infected erythrocytes in the placenta due to interactions between VAR2CSA protein, expressed on the surface of infected-erythrocytes, and placental chondroitin sulfate proteoglycans (CSPG). VAR2CSA contains multiple CSPG-bin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khunrae, Pongsak, Philip, Judith M.D., Bull, Duncan R., Higgins, Matthew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778748/ https://www.ncbi.nlm.nih.gov/pubmed/19695262 http://dx.doi.org/10.1016/j.jmb.2009.08.027

Ejemplares similares

Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies
por: Khunrae, Pongsak, et al.
Publicado: (2010)

Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
por: Gangnard, Stéphane, et al.
Publicado: (2015)

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A
por: Singh, Kavita, et al.
Publicado: (2008)

Identification and Characterization of B-Cell Epitopes in the DBL4ε Domain of VAR2CSA
por: Ditlev, Sisse B., et al.
Publicado: (2012)

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
por: Fernandez, Pablo, et al.
Publicado: (2008)

Towards the Rational Design of a Candidate Vaccine against Pregnancy Associated Malaria: Conserved Sequences of the DBL6ε Domain of VAR2CSA
por: Badaut, Cyril, et al.
Publicado: (2010)

Antibody responses to the full-length VAR2CSA and its DBL domains in Cameroonian children and teenagers
por: Fodjo, Barriere A. Y., et al.
Publicado: (2016)

Infections with Plasmodium falciparum during pregnancy affect VAR2CSA DBL-5 domain-specific T cell cytokine responses
por: Gbédandé, Komi, et al.
Publicado: (2016)

Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells
por: Wang, Chris Kedong, et al.
Publicado: (2022)

Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins
por: Avril, Marion, et al.
Publicado: (2011)

Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria
por: Talundzic, Eldin, et al.
Publicado: (2022)

Sequence Polymorphism, Segmental Recombination and Toggling Amino Acid Residues within the DBL3X Domain of the VAR2CSA Placental Malaria Antigen
por: Talundzic, Eldin, et al.
Publicado: (2012)

Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6∊-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum
por: Vuchelen, Anneleen, et al.
Publicado: (2013)

Insight into Antigenic Diversity of VAR2CSA-DBL5ε Domain from Multiple Plasmodium falciparum Placental Isolates
por: Gnidehou, Sédami, et al.
Publicado: (2010)

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain
por: Nunes-Silva, Sofia, et al.
Publicado: (2014)

Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria
por: Salanti, Ali, et al.
Publicado: (2004)

Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
por: Chêne, Arnaud, et al.
Publicado: (2018)

Plasmodium falciparum Variability and Immune Evasion Proceed from Antigenicity of Consensus Sequences from DBL6ε; Generalization to All DBL from VAR2CSA
por: Deloron, Philippe, et al.
Publicado: (2013)

Epitope Mapping and Topographic Analysis of VAR2CSA DBL3X Involved in P. falciparum Placental Sequestration
por: Dahlbäck, Madeleine, et al.
Publicado: (2006)

Antibodies to full-length and the DBL5 domain of VAR2CSA in pregnant women after long-term implementation of intermittent preventive treatment in Etoudi, Cameroon
por: Djontu, Jean Claude, et al.
Publicado: (2020)

Structural Insight into Epitopes in the Pregnancy-Associated Malaria Protein VAR2CSA
por: Andersen, Pernille, et al.
Publicado: (2008)

Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris
por: Avril, Marion, et al.
Publicado: (2009)

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding
por: Bewley, Maria C., et al.
Publicado: (2021)

Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region
por: Srivastava, Anand, et al.
Publicado: (2011)

Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under Flow Conditions
por: Fernandez, Pablo, et al.
Publicado: (2010)

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development
por: Benavente, Ernest Diez, et al.
Publicado: (2018)

Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
por: Barfod, Lea, et al.
Publicado: (2007)

Designing a VAR2CSA-based vaccine to prevent placental malaria()
por: Fried, Michal, et al.
Publicado: (2015)

Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA
por: Ma, Rui, et al.
Publicado: (2021)

Utilizing Nanobody Technology to Target Non-Immunodominant Domains of VAR2CSA
por: Ditlev, Sisse B., et al.
Publicado: (2014)

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains
por: Dahlbäck, Madeleine, et al.
Publicado: (2011)

Unravelling var complexity: Relationship between DBLα types and var genes in Plasmodium falciparum
por: Tan, Mun Hua, et al.
Publicado: (2022)

VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
por: Fonseca, Ana Maria, et al.
Publicado: (2019)

Analysis of var Gene Transcription Pattern Using DBLα Tags
por: Andisi, Kivisi C., et al.
Publicado: (2022)

A paradoxical population structure of var DBLα types in Africa
por: Tan, Mun Hua, et al.
Publicado: (2023)

Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype
por: Viebig, Nicola K., et al.
Publicado: (2007)

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
por: Wang, Kaituo, et al.
Publicado: (2021)

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains
por: Doritchamou, Justin Y. A., et al.
Publicado: (2019)

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
por: Renn, Jonathan P., et al.
Publicado: (2021)

High Avidity Antibodies to Full-Length VAR2CSA Correlate with Absence of Placental Malaria
por: Tutterrow, Yeung Lo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pj3qtk5o4v8t08qa827segs2t6