Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress

DNA damage triggers polyubiquitylation and degradation of the largest subunit of RNA polymerase II (RNAPII), a “mechanism of last resort” employed during transcription stress. In yeast, this process is dependent on Def1 through a previously unresolved mechanism. Here, we report that Def1 becomes act...

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Detalles Bibliográficos
Autores principales: Wilson, Marcus D., Harreman, Michelle, Taschner, Michael, Reid, James, Walker, Jane, Erdjument-Bromage, Hediye, Tempst, Paul, Svejstrup, Jesper Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778974/
https://www.ncbi.nlm.nih.gov/pubmed/23993092
http://dx.doi.org/10.1016/j.cell.2013.07.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778974/
https://www.ncbi.nlm.nih.gov/pubmed/23993092
http://dx.doi.org/10.1016/j.cell.2013.07.028

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