Cargando…
Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress
DNA damage triggers polyubiquitylation and degradation of the largest subunit of RNA polymerase II (RNAPII), a “mechanism of last resort” employed during transcription stress. In yeast, this process is dependent on Def1 through a previously unresolved mechanism. Here, we report that Def1 becomes act...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778974/ https://www.ncbi.nlm.nih.gov/pubmed/23993092 http://dx.doi.org/10.1016/j.cell.2013.07.028 |