Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress()

Multiple myeloma (MM) cells rely on protein homeostatic mechanisms for survival. These mechanisms could be therapeutically targeted via modulation of the heat shock response. We studied the roles of Hsp72 and Hsc70, and show that the two major cytoplasmic Hsp70s play a key role in regulating protein...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Fok, Jacqueline J.L., Mirabella, Fabio, Aronson, Lauren I., Fryer, Rosemary A., Workman, Paul, Morgan, Gareth J., Davies, Faith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778988/
https://www.ncbi.nlm.nih.gov/pubmed/23887058
http://dx.doi.org/10.1016/j.canlet.2013.07.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778988/
https://www.ncbi.nlm.nih.gov/pubmed/23887058
http://dx.doi.org/10.1016/j.canlet.2013.07.023

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