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T Cell and Dendritic Cell Abnormalities Synergize to Expand Pro-Inflammatory T Cell Subsets Leading to Fatal Autoimmunity in B6.NZBc1 Lupus-Prone Mice

We have previously shown that B6 congenic mice with a New Zealand Black chromosome 1 (c1) 96-100 cM interval produce anti-nuclear Abs and that at least two additional genetic loci are required to convert this subclinical disease to fatal glomerulonephritis in mice with a c1 70-100 cM interval (c1(70...

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Detalles Bibliográficos
Autores principales: Talaei, Nafiseh, Cheung, Yui-Ho, Landolt-Marticorena, Carolina, Noamani, Babak, Li, Timothy, Wither, Joan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779178/
https://www.ncbi.nlm.nih.gov/pubmed/24073245
http://dx.doi.org/10.1371/journal.pone.0075166