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4-Ethylphenyl-Cobalamin Impairs Tissue Uptake of Vitamin B(12) and Causes Vitamin B(12) Deficiency in Mice
Co(β)-4-ethylphenyl-cob(III) alamin (EtPhCbl) is an organometallic analogue of vitamin B(12) (CNCbl) which binds to transcobalamin (TC), a plasma protein that facilitates the cellular uptake of cobalamin (Cbl). In vitro assays with key enzymes do not convert EtPhCbl to the active coenzyme forms of C...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779197/ https://www.ncbi.nlm.nih.gov/pubmed/24073261 http://dx.doi.org/10.1371/journal.pone.0075312 |