Cargando…

4-Ethylphenyl-Cobalamin Impairs Tissue Uptake of Vitamin B(12) and Causes Vitamin B(12) Deficiency in Mice

Co(β)-4-ethylphenyl-cob(III) alamin (EtPhCbl) is an organometallic analogue of vitamin B(12) (CNCbl) which binds to transcobalamin (TC), a plasma protein that facilitates the cellular uptake of cobalamin (Cbl). In vitro assays with key enzymes do not convert EtPhCbl to the active coenzyme forms of C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mutti, Elena, Ruetz, Markus, Birn, Henrik, Kräutler, Bernhard, Nexo, Ebba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779197/ https://www.ncbi.nlm.nih.gov/pubmed/24073261 http://dx.doi.org/10.1371/journal.pone.0075312

Ejemplares similares

Maximal Load of the Vitamin B12 Transport System: A Study on Mice Treated for Four Weeks with High-Dose Vitamin B12 or Cobinamide
por: Lildballe, Dorte L., et al.
Publicado: (2012)

The Many Faces of Cobalamin (Vitamin B(12)) Deficiency
por: Wolffenbuttel, Bruce H.R., et al.
Publicado: (2019)

Vitamin B12 (Cobalamin) Deficiency in Overt and Subclinical Primary Hypothyroidism
por: Aon, Mohamed, et al.
Publicado: (2022)

Plasma Vitamin B12 Levels, High-Dose Vitamin B12 Treatment, and Risk of Dementia
por: Arendt, Johan Frederik Håkonsen, et al.
Publicado: (2021)

Vitamin B12 deficiency secondary to cobalamin F deficiency simulating dyskeratosis congenita
por: Altawil, Lama, et al.
Publicado: (2020)

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population
por: Greibe, Eva, et al.
Publicado: (2017)

Forms and Amounts of Vitamin B12 in Infant Formula: A Pilot Study
por: Greibe, Eva, et al.
Publicado: (2016)

Ultrafast Excited State Dynamics and Fluorescence from Vitamin B(12) and Organometallic [Co]–C≡C–R Cobalamins
por: Salerno, Elvin V., et al.
Publicado: (2020)

Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency
por: Obeid, Rima, et al.
Publicado: (2015)

Tissue distribution of oral vitamin B12 is influenced by B12 status and B12 form: an experimental study in rats
por: Kornerup, Linda S., et al.
Publicado: (2017)

Metabolic engineering of cobalamin (vitamin B(12)) production in Bacillus megaterium
por: Biedendieck, Rebekka, et al.
Publicado: (2010)

Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders
por: Andrès, Emmanuel, et al.
Publicado: (2018)

Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats
por: Greibe, Eva, et al.
Publicado: (2018)

Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study
por: Arendt, Johan Frederik Berg, et al.
Publicado: (2013)

Cobalamin (Vitamin B12) in Anticancer Photodynamic Therapy with Zn(II) Phthalocyanines
por: Mantareva, Vanya, et al.
Publicado: (2023)

The Soluble Receptor for Vitamin B(12) Uptake (sCD320) Increases during Pregnancy and Occurs in Higher Concentration in Urine than in Serum
por: Abuyaman, Omar, et al.
Publicado: (2013)

Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility(1)(2)(3)(4)(5)
por: Nexo, Ebba, et al.
Publicado: (2011)

Influences of Vitamin B(12) Supplementation on Cognition and Homocysteine in Patients with Vitamin B(12) Deficiency and Cognitive Impairment
por: Ueno, Asako, et al.
Publicado: (2022)

Vitamin B(12) deficiency
por: Silverstein, William K., et al.
Publicado: (2022)

Cyano-B12 or Whey Powder with Endogenous Hydroxo-B12 for Supplementation in B12 Deficient Lactovegetarians
por: Naik, Sadanand, et al.
Publicado: (2019)

Vitamin B(12) (Cobalamin) and Micronutrient Fortification in Food Crops Using Nanoparticle Technology
por: Oh, Soojin, et al.
Publicado: (2021)

Methylotrophic bacteria with cobalamin-dependent mutases in primary metabolism as potential strains for vitamin B(12) production
por: Dudko, Darya, et al.
Publicado: (2022)

Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians
por: Mahalle, Namita, et al.
Publicado: (2019)

Cobalamin Related Parameters and Disease Patterns in Patients with Increased Serum Cobalamin Levels
por: Arendt, Johan F. B., et al.
Publicado: (2012)

Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F
por: Mireku, S. A., et al.
Publicado: (2017)

Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: a multicentre pragmatic randomised controlled trial
por: Favrat, Bernard, et al.
Publicado: (2011)

Response of Human Glioblastoma Cells to Vitamin B12 Deficiency: A Study Using the Non-Toxic Cobalamin Antagonist
por: Rzepka, Zuzanna, et al.
Publicado: (2021)

Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin
por: Chen, Manyun, et al.
Publicado: (2023)

The Cobalamin-Binding Protein in Zebrafish Is an Intermediate between the Three Cobalamin-Binding Proteins in Human
por: Greibe, Eva, et al.
Publicado: (2012)

Microbial and Genetic Resources for Cobalamin (Vitamin B12) Biosynthesis: From Ecosystems to Industrial Biotechnology
por: Balabanova, Larissa, et al.
Publicado: (2021)

Vitamin B(12) deficiency & cognitive impairment in elderly population
por: Agarwal, Rachna
Publicado: (2011)

Effect of the vitamin B12-binding protein haptocorrin present in human milk on a panel of commensal and pathogenic bacteria
por: Jensen, Henrik R, et al.
Publicado: (2011)

Exceptional Photochemical Stability of the Co–C Bond of Alkynyl Cobalamins, Potential Antivitamins B(12) and Core Elements of B(12)-Based Biological Vectors
por: Salerno, Elvin V., et al.
Publicado: (2020)

Vitamin B12 deficiency and impaired expression of amnionless during aging
por: Pannérec, Alice, et al.
Publicado: (2017)

Zinc Substitution of Cobalt in Vitamin B(12): Zincobyric acid and Zincobalamin as Luminescent Structural B(12)‐Mimics
por: Kieninger, Christoph, et al.
Publicado: (2019)

Uncommon manifestations of Vitamin B(12) deficiency
por: Mohapatra, Rabindra N., et al.
Publicado: (2018)

Reversible hyperpigmentation of vitamin B12 deficiency
por: Vijayakumar, Kaleeswaran, et al.
Publicado: (2020)

Whippets Causing Vitamin B12 Deficiency
por: Maheshwari, Mani, et al.
Publicado: (2022)

Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic
por: Světnička, Martin, et al.
Publicado: (2022)

Cobalamin (Vitamin B12) Induced a Shift in Microbial Composition and Metabolic Activity in an in vitro Colon Simulation
por: Xu, Yuanyuan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ea1nb8gka3avjl450fejji7hdo