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Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor

The liver kinase B1 (LKB1) tumour suppressor functions as a master regulator of growth, metabolism and survival in cells, which is frequently mutated in sporadic human non-small cell lung and cervical cancers. LKB1 functions as a key upstream activator of the AMP-activated protein kinase (AMPK), a c...

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Detalles Bibliográficos
Autor principal: Shackelford, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779404/
https://www.ncbi.nlm.nih.gov/pubmed/24082825
http://dx.doi.org/10.4103/1477-3163.116323