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Pharmacophore Modeling and Docking Studies on Some Nonpeptide-Based Caspase-3 Inhibitors
Neurodegenerative disorders are major consequences of excessive apoptosis caused by a proteolytic enzyme known as caspase-3. Therefore, caspase-3 inhibition has become a validated therapeutic approach for neurodegenerative disorders. We performed pharmacophore modeling on some synthetic derivatives...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780516/ https://www.ncbi.nlm.nih.gov/pubmed/24089669 http://dx.doi.org/10.1155/2013/306081 |