Direct observation of frequency modulated transcription in single cells using light activation

Single-cell analysis has revealed that transcription is dynamic and stochastic, but tools are lacking that can determine the mechanism operating at a single gene. Here we utilize single-molecule observations of RNA in fixed and living cells to develop a single-cell model of steroid-receptor mediated...

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Detalles Bibliográficos
Autores principales: Larson, Daniel R, Fritzsch, Christoph, Sun, Liang, Meng, Xiuhau, Lawrence, David S, Singer, Robert H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780543/
https://www.ncbi.nlm.nih.gov/pubmed/24069527
http://dx.doi.org/10.7554/eLife.00750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780543/
https://www.ncbi.nlm.nih.gov/pubmed/24069527
http://dx.doi.org/10.7554/eLife.00750

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