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Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability

Common fragile sites (CFS) are heritable nonrandomly distributed loci on human chromosomes that exhibit an increased frequency of chromosomal breakage under conditions of replication stress. They are considered the preferential targets for high genomic instability from the earliest stages of human c...

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Detalles Bibliográficos
Autor principal: Franchitto, Annapaola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780545/
https://www.ncbi.nlm.nih.gov/pubmed/24083238
http://dx.doi.org/10.1155/2013/730714