Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox

Enzymes are proficient catalysts that enable fast rates of Michaelis-complex formation, the chemical step and products release. These different steps may require different conformational states of the active site that have distinct binding properties. Moreover, the conformational flexibility of the...

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Detalles Bibliográficos
Autores principales: Hiblot, Julien, Gotthard, Guillaume, Elias, Mikael, Chabriere, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781021/
https://www.ncbi.nlm.nih.gov/pubmed/24086491
http://dx.doi.org/10.1371/journal.pone.0075272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781021/
https://www.ncbi.nlm.nih.gov/pubmed/24086491
http://dx.doi.org/10.1371/journal.pone.0075272

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