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Protein Kinase A and C Regulate Leak Potassium Currents in Freshly Isolated Vascular Myocytes from the Aorta

We tested the hypothesis that protein kinase A (PKA) inhibits K2P currents activated by protein kinase C (PKC) in freshly isolated aortic myocytes. PDBu, the PKC agonist, applied extracellularly, increased the amplitude of the K2P currents in the presence of the “cocktail” of K(+) channel blockers....

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Detalles Bibliográficos
Autores principales: Hayoz, Sébastien, Cubano, Luis, Maldonado, Hector, Bychkov, Rostislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781042/
https://www.ncbi.nlm.nih.gov/pubmed/24086441
http://dx.doi.org/10.1371/journal.pone.0075077