Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody

To exploit the biological and pharmacological properties of immunoglobulin constant domain Fc fragment and increase the killing efficacy of T cells, a single chain variable fragment specific to CD3 was fused with Fcab (Fc antigen binding), a mutant Fc fragment with specificity against Human epiderma...

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Detalles Bibliográficos
Autores principales: Wang, Lei, He, Yanran, Zhang, Ge, Ma, Juan, Liu, Changzhen, He, Wen, Wang, Wei, Han, Huamin, Boruah, Bhargavi M., Gao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781095/
https://www.ncbi.nlm.nih.gov/pubmed/24086580
http://dx.doi.org/10.1371/journal.pone.0075589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781095/
https://www.ncbi.nlm.nih.gov/pubmed/24086580
http://dx.doi.org/10.1371/journal.pone.0075589

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