Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor

BACKGROUND: Edoxaban, an oral direct factor Xa inhibitor, is in development for thromboprophylaxis, including prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). P-glycoprotein (P-gp), an efflux transporter, modulates absorption and excretion of xenobiotics. Edoxaba...

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Detalles Bibliográficos
Autores principales: Mendell, Jeanne, Zahir, Hamim, Matsushima, Nobuko, Noveck, Robert, Lee, Frank, Chen, Shuquan, Zhang, George, Shi, Minggao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781304/
https://www.ncbi.nlm.nih.gov/pubmed/23784266
http://dx.doi.org/10.1007/s40256-013-0029-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781304/
https://www.ncbi.nlm.nih.gov/pubmed/23784266
http://dx.doi.org/10.1007/s40256-013-0029-0

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