Cargando…

CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling. Here, we s...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Rubeis, Silvia, Pasciuto, Emanuela, Li, Ka Wan, Fernández, Esperanza, Di Marino, Daniele, Buzzi, Andrea, Ostroff, Linnaea E., Klann, Eric, Zwartkruis, Fried J.T., Komiyama, Noboru H., Grant, Seth G.N., Poujol, Christel, Choquet, Daniel, Achsel, Tilmann, Posthuma, Danielle, Smit, August B., Bagni, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781321/ https://www.ncbi.nlm.nih.gov/pubmed/24050404 http://dx.doi.org/10.1016/j.neuron.2013.06.039

Ejemplares similares

The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
por: Domínguez-Iturza, Nuria, et al.
Publicado: (2019)

Sm-like proteins in the pathogenesis of Spinal Muscular Atrophy
por: Achsel, Tilmann, et al.
Publicado: (2015)

Absence of RNA‐binding protein FXR2P prevents prolonged phase of kainate‐induced seizures
por: Lo, Adrian C, et al.
Publicado: (2021)

Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus
por: Zhang, Yinhua, et al.
Publicado: (2019)

Overexpression of the autism candidate gene Cyfip1 pathologically enhances olivo-cerebellar signaling in mice
por: Busch, Silas E., et al.
Publicado: (2023)

FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability
por: Clifton, Nicholas E., et al.
Publicado: (2020)

SREBP modulates the NADP(+)/NADPH cycle to control night sleep in Drosophila
por: Mariano, Vittoria, et al.
Publicado: (2023)

Molecular Dissection of Neurodevelopmental Disorder-Causing Mutations in CYFIP2
por: Schaks, Matthias, et al.
Publicado: (2020)

Cyfip1 Regulates SynGAP1 at Hippocampal Synapses
por: Sahasrabudhe, Abhishek, et al.
Publicado: (2021)

Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex
por: Babbs, Richard K., et al.
Publicado: (2019)

Persistent up-regulation of polyribosomes at synapses during long-term memory, reconsolidation, and extinction of associative memory
por: Ostroff, Linnaea E., et al.
Publicado: (2022)

Haploinsufficiency of Cyfip1 Produces Fragile X-Like Phenotypes in Mice
por: Bozdagi, Ozlem, et al.
Publicado: (2012)

Drosophila cyfip Regulates Synaptic Development and Endocytosis by Suppressing Filamentous Actin Assembly
por: Zhao, Lu, et al.
Publicado: (2013)

Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition
por: Davenport, Elizabeth C., et al.
Publicado: (2019)

Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
por: De Rubeis, Silvia, et al.
Publicado: (2011)

Spatial Modeling of Vesicle Transport and the Cytoskeleton: The Challenge of Hitting the Right Road
por: Klann, Michael, et al.
Publicado: (2012)

Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control
por: di Penta, Alessandra, et al.
Publicado: (2009)

CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome
por: Abekhoukh, Sabiha, et al.
Publicado: (2014)

A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold
por: Marsden, Kurt C., et al.
Publicado: (2018)

New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes
por: Abekhoukh, Sabiha, et al.
Publicado: (2017)

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala
por: Ostroff, Linnaea E, et al.
Publicado: (2019)

Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks
por: Nebel, Rebecca A., et al.
Publicado: (2016)

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss
por: Tiwari, Sachin Suresh, et al.
Publicado: (2016)

CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma
por: Dziunycz, Piotr J., et al.
Publicado: (2017)

Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy
por: Zhang, Yinhua, et al.
Publicado: (2019)

Analysis and Experimental Validation of Rheumatoid Arthritis Innate Immunity Gene CYFIP2 and Pan-Cancer
por: Zhao, ZhenYu, et al.
Publicado: (2022)

CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers
por: Peng, Qiliang, et al.
Publicado: (2023)

Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease
por: Geuens, Thomas, et al.
Publicado: (2017)

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis
por: Groenewoud, Marlous J., et al.
Publicado: (2013)

The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines
por: Pathania, M, et al.
Publicado: (2014)

Behavioral training rescues motor deficits in Cyfip1 haploinsufficiency mouse model of autism spectrum disorders
por: Bachmann, Sven O., et al.
Publicado: (2019)

CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes
por: Fricano-Kugler, Catherine, et al.
Publicado: (2019)

Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice
por: Kim, Gyu Hyun, et al.
Publicado: (2020)

Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity
por: Zemojtel, Tomasz, et al.
Publicado: (2010)

Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton
por: Lambert, Mireille, et al.
Publicado: (2002)

MreBCD-associated Cytoskeleton is Required for Proper Segregation of the Chromosomal Terminus during the Division Cycle of Escherichia Coli
por: Huo, Yu-Jia, et al.
Publicado: (2015)

Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
por: Silva, Ana I., et al.
Publicado: (2019)

The Downregulation of Prognosis- and Immune Infiltration-Related Gene CYFIP2 Serves as a Novel Target in ccRCC
por: Tong, Junwei, et al.
Publicado: (2021)

Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity
por: Chaya, Taro, et al.
Publicado: (2021)

BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses
por: Lacoux, Caroline, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_5a58e4kg8fqceikn7hetp1oie2