Cargando…

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development

Prohibitins are highly conserved proteins mainly implicated in the maintenance of mitochondrial function and architecture. Their dysfunctions are associated with aging, cancer, obesity, and inflammation. However, their possible role in pancreatic β-cells remains unknown. The current study documents...

Descripción completa

Detalles Bibliográficos
Autores principales:	Supale, Sachin, Thorel, Fabrizio, Merkwirth, Carsten, Gjinovci, Asllan, Herrera, Pedro L., Scorrano, Luca, Meda, Paolo, Langer, Thomas, Maechler, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781460/ https://www.ncbi.nlm.nih.gov/pubmed/23863811 http://dx.doi.org/10.2337/db13-0152

Ejemplares similares

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration
por: Merkwirth, Carsten, et al.
Publicado: (2012)

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes
por: Casimir, Marina, et al.
Publicado: (2011)

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice
por: He, Kai Hui Hu, et al.
Publicado: (2011)

Prohibitins in neurodegeneration and mitochondrial homeostasis
por: Fernandez-Abascal, Jesus, et al.
Publicado: (2022)

Opposing function of mitochondrial prohibitin in aging
por: Artal-Sanz, Marta, et al.
Publicado: (2010)

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival
por: Martin, David, et al.
Publicado: (2012)

High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets
por: Lamprianou, Smaragda, et al.
Publicado: (2011)

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice
por: Vinet, Laurent, et al.
Publicado: (2014)

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis
por: Jackson, Dakota N, et al.
Publicado: (2020)

Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex
por: Hernando-Rodríguez, Blanca, et al.
Publicado: (2018)

Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases
por: Signorile, Anna, et al.
Publicado: (2019)

The Effect of Prohibitins on Mitochondrial Function during Octopus tankahkeei Spermiogenesis
por: Wang, Jingqian, et al.
Publicado: (2023)

Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
por: Bassi, Geetika, et al.
Publicado: (2021)

Prohibitin involvement in the generation of mitochondrial superoxide at complex I in human sperm
por: Chai, Ran‐Ran, et al.
Publicado: (2016)

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
por: Huang, Haohao, et al.
Publicado: (2021)

The Mitochondrial Prohibitin (PHB) Complex in C. elegans Metabolism and Ageing Regulation
por: Lourenço, Artur B., et al.
Publicado: (2021)

Characterization of Mitochondrial Prohibitin in Opsariichthys bidens and Its Potential Functions in Spermatogenesis
por: Wang, Li, et al.
Publicado: (2022)

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation
por: Moncunill-Massaguer, Cristina, et al.
Publicado: (2015)

Induction of Paclitaxel Resistance by ERα Mediated Prohibitin Mitochondrial-Nuclear Shuttling
por: Dong, Pei, et al.
Publicado: (2013)

The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies
por: Ross, Jeremy A., et al.
Publicado: (2017)

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria
por: Korwitz, Anne, et al.
Publicado: (2016)

Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
por: Della-Flora Nunes, Gustavo, et al.
Publicado: (2021)

Conversion of Adult Pancreatic α-cells to β-cells After Extreme β-cell Loss
por: Thorel, Fabrizio, et al.
Publicado: (2010)

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice
por: Thorel, Fabrizio, et al.
Publicado: (2011)

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
por: Schleicher, Michael, et al.
Publicado: (2008)

Mitochondrial Dysfunction and Adipogenic Reduction by Prohibitin Silencing in 3T3-L1 Cells
por: Liu, Dong, et al.
Publicado: (2012)

Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells
por: Kathiria, Arwa S., et al.
Publicado: (2012)

Prohibitin-mediated mitochondrial ubiquitination during spermiogenesis in Chinese mitten crab Eriocheir sinensis
por: Hou, Cong-Cong, et al.
Publicado: (2017)

Prohibitin 1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers
por: Kong, Bao, et al.
Publicado: (2022)

Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy
por: Yan, Yaqin, et al.
Publicado: (2022)

The Prohibitins: emerging roles in diverse functions
por: Mishra, Suresh, et al.
Publicado: (2006)

The function of prohibitins in mitochondria and the clinical potentials
por: Oyang, Linda, et al.
Publicado: (2022)

CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription
por: Sun, Luguo, et al.
Publicado: (2011)

The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria
por: Osman, Christof, et al.
Publicado: (2009)

Damage Adaptive Titanium Alloy by In-Situ Elastic Gradual Mechanism
por: Zhang, Siqian, et al.
Publicado: (2020)

COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity
por: Jia, Yiting, et al.
Publicado: (2018)

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region
por: Yoshinaka, Takahiro, et al.
Publicado: (2019)

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
por: Alula, Kibrom M., et al.
Publicado: (2023)

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA
por: Parone, Philippe A., et al.
Publicado: (2008)

Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
por: Liu, Yu-Huei, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_d61uctue6gd5mqc6gg6n46pibh