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Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch

Purine riboswitches play an essential role in genetic regulation of bacterial metabolism. This family includes the 2′-deoxyguanosine (dG) riboswitch, involved in feedback control of deoxyguanosine biosynthesis. To understand the principles that define dG selectivity, we determined crystal structures...

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Detalles Bibliográficos
Autores principales: Pikovskaya, Olga, Polonskaia, Anna, Patel, Dinshaw J., Serganov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781940/
https://www.ncbi.nlm.nih.gov/pubmed/21841796
http://dx.doi.org/10.1038/nchembio.631