Approaching untargetable tumor-associated antigens with antibodies

Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm’s tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity an...

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Detalles Bibliográficos
Autores principales: Dao, Tao, Liu, Cheng, Scheinberg, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782011/
https://www.ncbi.nlm.nih.gov/pubmed/24073363
http://dx.doi.org/10.4161/onci.24678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782011/
https://www.ncbi.nlm.nih.gov/pubmed/24073363
http://dx.doi.org/10.4161/onci.24678

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