Approaching untargetable tumor-associated antigens with antibodies

Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm’s tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity an...

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Detalles Bibliográficos
Autores principales: Dao, Tao, Liu, Cheng, Scheinberg, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782011/
https://www.ncbi.nlm.nih.gov/pubmed/24073363
http://dx.doi.org/10.4161/onci.24678
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author Dao, Tao
Liu, Cheng
Scheinberg, David A.
author_facet Dao, Tao
Liu, Cheng
Scheinberg, David A.
author_sort Dao, Tao
collection PubMed
description Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm’s tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity and exert robust antineoplastic effects against human cancers that express WT1 epitopes on HLA-A201 molecules.
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spelling pubmed-37820112013-09-26 Approaching untargetable tumor-associated antigens with antibodies Dao, Tao Liu, Cheng Scheinberg, David A. Oncoimmunology Author's View Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm’s tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity and exert robust antineoplastic effects against human cancers that express WT1 epitopes on HLA-A201 molecules. Landes Bioscience 2013-07-01 2013-04-30 /pmc/articles/PMC3782011/ /pubmed/24073363 http://dx.doi.org/10.4161/onci.24678 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Dao, Tao
Liu, Cheng
Scheinberg, David A.
Approaching untargetable tumor-associated antigens with antibodies
title Approaching untargetable tumor-associated antigens with antibodies
title_full Approaching untargetable tumor-associated antigens with antibodies
title_fullStr Approaching untargetable tumor-associated antigens with antibodies
title_full_unstemmed Approaching untargetable tumor-associated antigens with antibodies
title_short Approaching untargetable tumor-associated antigens with antibodies
title_sort approaching untargetable tumor-associated antigens with antibodies
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782011/
https://www.ncbi.nlm.nih.gov/pubmed/24073363
http://dx.doi.org/10.4161/onci.24678
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