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Approaching untargetable tumor-associated antigens with antibodies
Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm’s tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity an...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782011/ https://www.ncbi.nlm.nih.gov/pubmed/24073363 http://dx.doi.org/10.4161/onci.24678 |