The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium

Homeostatic TLR4 signaling protects the intestinal epithelium in health. Evidence suggests that perturbed TLR4 signaling is linked to carcinogenesis. We have recently demonstrated that the common human TLR4 variant D299G exerts pro-inflammatory effects and drives malignant tumor progression in human...

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Detalles Bibliográficos
Autor principal: Cario, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782013/
https://www.ncbi.nlm.nih.gov/pubmed/24073372
http://dx.doi.org/10.4161/onci.24890
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author Cario, Elke
author_facet Cario, Elke
author_sort Cario, Elke
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description Homeostatic TLR4 signaling protects the intestinal epithelium in health. Evidence suggests that perturbed TLR4 signaling is linked to carcinogenesis. We have recently demonstrated that the common human TLR4 variant D299G exerts pro-inflammatory effects and drives malignant tumor progression in human colon cancer.
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spelling pubmed-37820132013-09-26 The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium Cario, Elke Oncoimmunology Author's View Homeostatic TLR4 signaling protects the intestinal epithelium in health. Evidence suggests that perturbed TLR4 signaling is linked to carcinogenesis. We have recently demonstrated that the common human TLR4 variant D299G exerts pro-inflammatory effects and drives malignant tumor progression in human colon cancer. Landes Bioscience 2013-07-01 2013-05-07 /pmc/articles/PMC3782013/ /pubmed/24073372 http://dx.doi.org/10.4161/onci.24890 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Cario, Elke
The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
title The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
title_full The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
title_fullStr The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
title_full_unstemmed The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
title_short The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
title_sort human tlr4 variant d299g mediates inflammation-associated cancer progression in the intestinal epithelium
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782013/
https://www.ncbi.nlm.nih.gov/pubmed/24073372
http://dx.doi.org/10.4161/onci.24890
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