p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

The induction of cellular senescence is an important mechanism by which p53 suppresses tumorigenesis. Using a mouse model of liver carcinoma, where cellular senescence is triggered in vivo by inducible p53 expression, we demonstrated that NK cells participate in the elimination of senescent tumors....

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Detalles Bibliográficos
Autores principales: Iannello, Alexandre, Thompson, Thornton W., Ardolino, Michele, Lowe, Scott W., Raulet, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782044/
https://www.ncbi.nlm.nih.gov/pubmed/24043758
http://dx.doi.org/10.1084/jem.20130783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782044/
https://www.ncbi.nlm.nih.gov/pubmed/24043758
http://dx.doi.org/10.1084/jem.20130783

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