Cargando…

CD4(+) T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

Synthetic glucocorticoids (GCs) are commonly used in the treatment of inflammatory diseases, but the role of endogenous GCs in the regulation of host-protective immune responses is poorly understood. Here we show that GCs are induced during acute Toxoplasma gondii infection and directly control the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kugler, David G., Mittelstadt, Paul R., Ashwell, Jonathan D., Sher, Alan, Jankovic, Dragana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782051/ https://www.ncbi.nlm.nih.gov/pubmed/23980098 http://dx.doi.org/10.1084/jem.20122300

Ejemplares similares

Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes
por: Kugler, David G., et al.
Publicado: (2016)

Thymus-derived Glucocorticoids Regulate Antigen-specific Positive Selection
por: Vacchio, Melanie S., et al.
Publicado: (1997)

Fibrin-mediated Protection Against Infection-stimulated Immunopathology
por: Johnson, Lawrence L., et al.
Publicado: (2003)

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
por: Steinfelder, Svenja, et al.
Publicado: (2009)

Long-term survival of influenza virus infected club cells drives immunopathology
por: Heaton, Nicholas S., et al.
Publicado: (2014)

Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus
por: Smit, Joost J., et al.
Publicado: (2006)

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge
por: Hilligan, Kerry L., et al.
Publicado: (2021)

Quantitative Contribution of CD4 and CD8 to T Cell Antigen Receptor Serial Triggering
por: Viola, Antonella, et al.
Publicado: (1997)

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza
por: Rappe, Julie C.F., et al.
Publicado: (2021)

Role of HMGB1 in apoptosis-mediated sepsis lethality
por: Qin, Shixin, et al.
Publicado: (2006)

Innate recognition of Toxoplasma gondii in humans involves a mechanism distinct from that utilized by rodents
por: Sher, Alan, et al.
Publicado: (2017)

Cholera toxin inhibits IL-12 production and CD8α(+) dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
por: la Sala, Andrea, et al.
Publicado: (2009)

Antigen-responsive CD4(+) T cell clones contribute to the HIV-1 latent reservoir
por: Mendoza, Pilar, et al.
Publicado: (2020)

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
por: Hermanova, Ivana, et al.
Publicado: (2020)

Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages
por: Ling, Yun M., et al.
Publicado: (2006)

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder
por: Salmena, Leonardo, et al.
Publicado: (2005)

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
por: Huston, Jared M., et al.
Publicado: (2006)

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
por: Wirtz, Stefan, et al.
Publicado: (2006)

A Mediator Role For Metallothionein in Tumor Necrosis Factor–induced Lethal Shock
por: Waelput, Wim, et al.
Publicado: (2001)

Type I interferon drives tumor necrosis factor–induced lethal shock
por: Huys, Liesbeth, et al.
Publicado: (2009)

Resistance to and Recovery from Lethal Influenza Virus Infection in B Lymphocyte–deficient Mice
por: Graham, Mary Beth, et al.
Publicado: (1997)

The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine
por: Mueller, Matthias, et al.
Publicado: (2006)

Nuclear Factor of Activated T Cells Transcription Factor Nfatp Controls Superantigen-Induced Lethal Shock
por: Tsytsykova, Alla V., et al.
Publicado: (2000)

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
por: Ito, Kazuhiro, et al.
Publicado: (2006)

Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells
por: Nishikawa, Hiroyoshi, et al.
Publicado: (2005)

Parasite-induced Lipoxin A(4) Is an Endogenous Regulator of IL-12 Production and Immunopathology in Toxoplasma gondii Infection
por: Aliberti, Julio, et al.
Publicado: (2002)

CD8(+) T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy
por: Sutter, Pearl A., et al.
Publicado: (2023)

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice
por: M.Gaspal, Fabrina, et al.
Publicado: (2011)

Vα14 NK T cell–triggered IFN-γ production by Gr-1(+)CD11b(+) cells mediates early graft loss of syngeneic transplanted islets
por: Yasunami, Yohichi, et al.
Publicado: (2005)

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes
por: Oguro, Hideyuki, et al.
Publicado: (2012)

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
por: Tran, Eric, et al.
Publicado: (2013)

Cd47 (Integrin-Associated Protein) Engagement of Dendritic Cell and Macrophage Counterreceptors Is Required to Prevent the Clearance of Donor Lymphohematopoietic Cells
por: Blazar, Bruce R., et al.
Publicado: (2001)

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
por: Hammer, Michael, et al.
Publicado: (2006)

Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis
por: Li, Caiyi C., et al.
Publicado: (2015)

Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing
por: Svensson, Camilla I., et al.
Publicado: (2007)

Restoration of CD28 Expression in CD28(−) CD8(+) Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production
por: Topp, Max S., et al.
Publicado: (2003)

CD40-deficient, Influenza-specific CD8 Memory T Cells Develop and Function Normally in a CD40-sufficient Environment
por: Lee, Byung O., et al.
Publicado: (2003)

TAP-1 indirectly regulates CD4(+) T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-γ production
por: Goldszmid, Romina S., et al.
Publicado: (2007)

Complement drives Th17 cell differentiation and triggers autoimmune arthritis
por: Hashimoto, Motomu, et al.
Publicado: (2010)

Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation
por: Jenkinson, S. Rhiannon, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_83us9v3936p7fn6vq5dtnlm87i