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Neuroprotective intervention by interferon-γ blockade prevents CD8(+) T cell–mediated dendrite and synapse loss
Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons in...
Autores principales: | Kreutzfeldt, Mario, Bergthaler, Andreas, Fernandez, Marylise, Brück, Wolfgang, Steinbach, Karin, Vorm, Mariann, Coras, Roland, Blümcke, Ingmar, Bonilla, Weldy V., Fleige, Anne, Forman, Ruth, Müller, Werner, Becher, Burkhard, Misgeld, Thomas, Kerschensteiner, Martin, Pinschewer, Daniel D., Merkler, Doron |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782053/ https://www.ncbi.nlm.nih.gov/pubmed/23999498 http://dx.doi.org/10.1084/jem.20122143 |
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