Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia

In neurodegenerative conditions and following brain trauma it is not understood why neurons die while astrocytes and microglia survive and adopt pro-inflammatory phenotypes. We show here that the damaged adult brain releases diffusible factors that can kill cortical neurons and we have identified hi...

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Detalles Bibliográficos
Autores principales: Gilthorpe, Jonathan D, Oozeer, Fazal, Nash, Julia, Calvo, Margarita, Bennett, David LH, Lumsden, Andrew, Pini, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782347/
https://www.ncbi.nlm.nih.gov/pubmed/24358859
http://dx.doi.org/10.12688/f1000research.2-148.v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782347/
https://www.ncbi.nlm.nih.gov/pubmed/24358859
http://dx.doi.org/10.12688/f1000research.2-148.v1

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