Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding

The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E-BP1 on amino acids Thr37 and/or Thr46 represen...

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Detalles Bibliográficos
Autores principales: Livingstone, Mark, Bidinosti, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782355/
https://www.ncbi.nlm.nih.gov/pubmed/24358826
http://dx.doi.org/10.12688/f1000research.1-4.v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782355/
https://www.ncbi.nlm.nih.gov/pubmed/24358826
http://dx.doi.org/10.12688/f1000research.1-4.v1

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