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Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E-BP1 on amino acids Thr37 and/or Thr46 represen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000Research
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782355/ https://www.ncbi.nlm.nih.gov/pubmed/24358826 http://dx.doi.org/10.12688/f1000research.1-4.v1 |