Regulation of PTEN/Akt Pathway Enhances Cardiomyogenesis and Attenuates Adverse Left Ventricular Remodeling following Thymosin β4 Overexpressing Embryonic Stem Cell Transplantation in the Infarcted Heart

Thymosin β4 (Tβ4), a small G-actin sequestering peptide, mediates cell proliferation, migration, and angiogenesis. Whether embryonic stem (ES) cells, overexpressing Tβ4, readily differentiate into cardiac myocytes in vitro and in vivo and enhance cardioprotection following transplantation post myoca...

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Detalles Bibliográficos
Autores principales: Yan, Binbin, Singla, Reetu D., Abdelli, Latifa S., Singal, Pawan K., Singla, Dinender K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782449/
https://www.ncbi.nlm.nih.gov/pubmed/24086577
http://dx.doi.org/10.1371/journal.pone.0075580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782449/
https://www.ncbi.nlm.nih.gov/pubmed/24086577
http://dx.doi.org/10.1371/journal.pone.0075580

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